Tyrrell County is a county located in the U.S. state of North Carolina. As of 2000, the population was 4,149, making it the least populous county in the state. Its county seat is Columbia.
The county was formed in 1729 as Tyrrell Precinct of Albemarle County, from parts of Bertie Precinct, Chowan Precinct, Currituck Precinct, and Pasquotank Precinct. It was named for Sir John Tyrrell, one of the Lords Proprietors of Carolina.
With the abolition of Albemarle County in 1739, all of its constituent precincts became counties. In 1774 the western part of Tyrrell County was combined with part of Halifax County to form Martin County. In 1799 the western third of what was left of Tyrrell County became Washington County. In 1870 the half of Tyrrell County east of the Alligator River was combined with parts of Currituck County and Hyde County to form Dare County.