Northampton County is a county located in the U.S. state of North Carolina. As of 2000, the population was 22,086. Its county seat is Jackson.
Northampton County is part of the Roanoke Rapids, North Carolina, Micropolitan Statistical Area.
The county was formed in 1741 from Bertie County. It was named for James Compton, 5th Earl of Northampton.
In 1759 parts of Northampton County, Bertie County, and Chowan County were combined to form Hertford County.